Would you like to join a team that focuses on analytical investigations for research-grade drug substances, adjutants and drug products for the Bacterial Vaccines department (part of Johnson & Johnson Innovative Medicine in Leiden). The team consists of 10+ employees with backgrounds in Biophysical and Biochemical Assays, Mass Spectrophotometry, Liquid Chromatography, Capillary Electrophoresis and Automation.
- 02 januari 2025
- vacaturenummer: 676313
€650 per month, fulltime
Behind the scenes at a big healthcare company
Develop your personal and business skills
Grow your theoretical and practical knowledge
Possible to travel by public or own transport
You are following a Master in the field of Analytical Chemistry, Pharmaceutical Sciences, Life Sciences, or any other relevant studies. Further you:
- Are available for a minimum of 9 months
- Are available for 40 hours per week
- Have knowledge of Microsoft Office
- Are good in English, both verbally and in writing
- Are able to work independently and in a team
- Are a problem-solver
The Bacterial Vaccines department is currently developing adjuvanted vaccine formulations. It is critical
to assess the quality and stability of those adjuvants alone and after mixing with antigens to create a candidate drug product. One of the focus areas of the Analytical Development team is to develop analytical tools that provide insight into the interaction between antigens and adjuvants and study the impact on the drug product formulation. Analysis of a nanoparticulate adjuvant system in combination with glycoconjugates and proteins is a major challenge in the field of vaccines but at the same time critical to understand immunogenic potential and efficacy of a vaccine 1,2. Routinely, we use an array of various biophysical techniques to characterize those formulations. In the current project, we plan to develop a set of methods to characterize liposomal and/or oil-in-water adjuvant formulations.
- Implement an AF4-MALS (Asymmetric-Flow Field-Flow Fractionation- Multi Angle Light Scattering) protocol that was developed externally
- Then, optimize the protocol for the antigen-adjuvant combinations that are relevant for our current candidate bacterial vaccine compositions.
- Test resolution of antigens, aggregates, fragments and adjuvants.
- Assess whether the method can be used to investigate interactions between antigens and adjuvants.
The Bacterial Vaccines department, part of Johnson & Johnson Innovative Medicine, is located in Leiden
Bio-Science Park (Archimedesweg 6, 2333 CN). Bacterial Vaccines has well-equipped laboratories and collaborates with other departments in Leiden, such as Vaccine Process & Analytical Development (VPAD) and Quality Control (QC), which provide expertise to Bacterial Vaccines and its external partners for the development of their prototype vaccines.
Are you the candidate we are looking for? Don't hesitate to respond, using the button below.
Dillon Banks
Recruiter
Do you want more information, or do you have questions about this internship? Please send us an e-mail.
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